Olyset^® nets are highly effective in killing anopheline mosquitoes within 3 min of exposure, as evidenced in cone bioassay tests. These nets also showed their efficacy on other vector mosquitoes (Aedes aegypti and Cx. quinquefasciatus) at higher exposure periods. The efficacy remained at ~90% even after 20 washings at an interval of 24 h against Anopheles culicifacies and Cx. quinquefasciatus. Use of the nets inside the house also resulted in drastic reduction of daytime resting density of mosquitoes because of high repellency, excitorepellency, and killing action of the nets. Pilot studies are indicated to evaluate the impact of use of Olyset nets on vector-borne diseases, particularly malaria, and its cost-effectiveness in comparison to conventional indoor residual spraying.